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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
15.45
Human Site:
S1247
Identified Species:
24.29
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1247
K
N
E
N
T
E
G
S
P
Q
E
D
G
V
E
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
A1289
F
D
E
E
F
S
G
A
P
V
E
G
A
G
E
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
A1280
S
G
V
P
V
E
G
A
G
E
E
A
L
I
P
Dog
Lupus familis
XP_537646
1532
174610
S1247
K
N
E
N
T
E
G
S
P
Q
E
E
S
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
T1245
K
S
E
N
V
E
G
T
P
A
E
D
G
A
E
Rat
Rattus norvegicus
P41516
1526
173202
T1244
K
S
E
N
V
E
G
T
P
A
E
D
G
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S1278
K
S
E
T
S
A
G
S
S
P
E
D
K
E
P
Chicken
Gallus gallus
O42130
1553
174974
D1248
K
S
E
K
N
E
S
D
E
K
Q
E
G
N
S
Frog
Xenopus laevis
NP_001082502
1579
178601
E1244
E
D
V
A
K
K
M
E
F
D
D
D
G
G
E
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
A1256
F
D
D
E
A
D
A
A
A
D
G
T
G
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
S1174
D
D
L
D
A
L
E
S
K
L
N
E
V
E
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
A1239
R
E
K
A
D
Q
D
A
S
I
K
N
A
A
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
K1174
L
L
K
Q
R
D
E
K
A
A
E
L
S
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
I1191
I
E
A
A
Q
K
K
I
R
A
K
S
G
A
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
N1156
L
S
A
K
D
I
W
N
T
D
L
K
A
F
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
33.3
20
80
N.A.
66.6
66.6
N.A.
40
26.6
20
13.3
N.A.
13.3
N.A.
0
6.6
P-Site Similarity:
100
46.6
40
93.3
N.A.
80
80
N.A.
53.3
53.3
46.6
40
N.A.
33.3
N.A.
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
20
14
7
7
27
14
27
0
7
20
27
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
27
7
7
14
14
7
7
0
20
7
34
0
0
0
% D
% Glu:
7
14
47
14
0
40
14
7
7
7
54
20
0
14
54
% E
% Phe:
14
0
0
0
7
0
0
0
7
0
0
0
0
7
0
% F
% Gly:
0
7
0
0
0
0
47
0
7
0
7
7
47
14
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
0
7
0
7
0
7
0
0
0
14
0
% I
% Lys:
40
0
14
14
7
14
7
7
7
7
14
7
7
0
7
% K
% Leu:
14
7
7
0
0
7
0
0
0
7
7
7
7
7
7
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
14
0
27
7
0
0
7
0
0
7
7
0
7
0
% N
% Pro:
0
0
0
7
0
0
0
0
34
7
0
0
0
0
14
% P
% Gln:
0
0
0
7
7
7
0
0
0
14
7
0
0
0
0
% Q
% Arg:
7
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% R
% Ser:
7
34
0
0
7
7
7
27
14
0
0
7
14
0
7
% S
% Thr:
0
0
0
7
14
0
0
14
7
0
0
7
0
0
0
% T
% Val:
0
0
14
0
20
0
0
0
0
7
0
0
7
14
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _